The lack of association with herbal tea intake in the UK Biobank study was attributed to that it is not consumed in high quantities, or that it is not used as a replacement of caffeinated beverages (as black tea, containing more caffeine than green tea, is the regular tea beverage in the UK). A possible explanation to our finding of coffee preference instead of tea in rs2470893 SNP A allele carriers could be the automatic limitation of the consumption of other drinks among habitual coffee consumers (rs2470893 SNP A carriers), as a person has to consume only a certain number of drinks per day. However, the strong inverse correlation between the two beverages intake observed in rs2470893 A allele carriers disappeared when analyzing rs2470893 GG genotype carriers, suggesting a direct link between genotype and beverage preference. Nevertheless, the preference could not be attributed to the higher caffeine content of coffee, as a cup of green tea decoction contains more caffeine than a coffee cupcup of coffee. Other issues should be explored to explain such beverage preference according to CYP1A2 rs2470893 SNP genotypes, with relation to caffeine metabolism rate, or bitter taste perception. Indeed, the inducing effect of coffee on CYP1A2 activity is more pronounced than that of heavy tea consumption, through the other coffee components (such as polycyclic aromatic hydrocarbons), which suggests a faster caffeine metabolism rate after coffee ingestion. In the study of Masi et al. (2016), the authors showed that the preference for stronger coffee flavor is consequent to regular coffee consumption, that induces faster caffeine metabolism and lower sensitivity to bitter taste. Similarly, this situation of a higher coffee intake, in addition to the faster caffeine metabolism rate that would occur in rs2470893 SNP A allele carriers, could explain the observed coffee preference instead of tea.